Monica Vinader

A Step Closer To Immortality – Scientists Discover New Drug To Reverse Ageing

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A Step Closer To Immortality - Scientists Discover New Drug To Reverse Ageing
A Step Closer To Immortality – Scientists Discover New Drug To Reverse Ageing

Why do we age?

Ageing altogether is a mysterious process. However, science recognizes cellular level damage as one of the main factors when it comes to ageing. As we get old, our DNA repair mechanism deteriorates resulting in permanent errors and cell mutations. Once DNA has become too damaged, cells kill themselves or become dormant leading to ageing and illnesses such as Alzheimer’s and cancer.

What triggers DNA deterioration is a separate issue. The most common causes are UV radiation and free radicals.

Free Radicals

As we breathe, a free radical occurs when an oxygen molecule splits into single atoms with unpaired electrons. Electrons like to be in pairs, so these atoms (free radicals), scavenge our body for electrons they can pair-up with. They steal other cells’ electrons causing DNA deterioration and eventually cells to die. To prevent free radical damage, our body has a defense system of antioxidants. Their role is to donate their electrons to free radicals before they damage healthy cells.

This kind of damage can be worsened by external factors such as fried food, alcohol, pesticides, smoking, and air pollutants. And this is why doctors can’t emphasize enough the importance of SPF and maintaining a healthy antioxidant-rich diet. The principle vitamin antioxidants are Vitamin A, B, C, E, Reservatol, Glutathione and Selenium;

Dr David Sinclair

Dr David Sinclair, professor of genetics at the Harvard Medical School has dedicated many years researching the ageing process and how to slow its effects. In particular he is known for his work on Reservatol. Thanks to his research, this antioxidant has been under the anti-aging spotlight over the past decade.

However, Dr Sinclair recently discovered another critical step in ageing. This step is associated with decreasing levels of NAD+ in our bodies, which inevitably causes DNA deterioration and consequently ageing. ¹

So What Is NAD+?

Nicotinamide adenine dinucleotide (NAD+) is a molecule in our bodies that is responsible for proper bodily function on a cellular level. NAD+ helps transfer energy from food into fuel that eventually powers up our cells – cells need energy to function and reproduce.

In addition, NAD+ in its oxidized form (NADH), also has the strongest positive effect in fighting the threat of free radicals and the damage they cause. Basically think of it as ‘Reservatol on steroids’!

Unfortunately, NAD+ levels significantly decrease as we age. By the time we turn 30, we lose 50% of NAD+. And that explains why we tend to start to feel less energetic. Moreover, lower levels of NAD+ in our bodies prevent DNA from being repaired as efficiently, essentially leaving our cells vulnerable to damage.

NMN Drug

NAD+ quickly became the center of our attention on 24 March 2017 when Science Magazine published new findings, which offered a critical insight into a previously unknown role of NAD+ in DNA repair.

Additionally, Dr Sinclair’s lab conducted an experiment which involved giving NMN (a NAD+ boosting drug) for one week to ageing mice. They found that NMN had a dramatic rejuvenating effect as is extremely efficient in repairing damaged cells. In fact, two year old mice tissue started to resemble that of six month old mice tissue. In human years, that would be akin to a 60 year old’s cells becoming more like those of a 20 year old. ²

Even though human clinical studies haven’t taken place yet, scientists feel very optimistic about these findings. And more research is on the way. Dr Sinclair commented to Sky News:

“The cells of the old mice were indistinguishable from the young mice, after just one week of treatment. This is the closest we are to a safe and effective anti-ageing drug that’s perhaps only three to five years away from being on the market if the trials go well.” ³

My Beauty Insider says

While NAD+ may be the source of the fountain of youth, unless you’re a middle-aged mouse, I would still hold off with NAD+ supplements. The effects of such substances are often not the same for humans, considering the vast differences in our biology vs that of mice. Having said that, keep your eyes open as human clinical trials are due to begin this year.

I am very hopeful about NAD+. While it may not make us immortal, it sounds like it could definitely buy us some time!

References and Sources

  1. https://www.ncbi.nlm.nih.gov/pubmed/24360282
  2. http://healthland.time.com/2013/12/19/reversing-aging-not-as-crazy-as-you-think/
  3. http://news.sky.com/story/age-reversal-drug-could-be-on-market-in-three-years-10811978
  4. http://www.hms.harvard.edu/agingresearch/index.php/about/staff/sinclair
  5. http://news.harvard.edu/gazette/story/2017/03/harvard-scientists-pinpoint-critical-step-in-dna-repair-cellular-aging/
  6. http://genetics.med.harvard.edu/sinclair/research.php
  7. https://blogs.scientificamerican.com/guest-blog/beyond-resveratrol-the-anti-aging-nad-fad/
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I'm a London based beauty researcher who is continuously on the hunt for the preventative and corrective skincare products and treatments and award-winning spas around the globe.

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